Complete list of publications
-
Research Articles
2025
95. A. Dash, A.S. Kulkarni, F.. Irshad, D.P. Masal, D. Manhas, U. Nandi, D. S. Reddy, A. Goswami. The interplay between genotoxic stress and STING activation in cellular senescence and inflammatory responses. International Immunopharmacology 2025, 164, 115371.
https://doi.org/10.1016/j.intimp.2025.115371
94. S.A. Haq, N. Banjare, D. Kumar, S. Dhiman, B. Viz, U. Nandi, Z. Ahmed, P.N. Gupta. Self-emulsifying formulation of andrographolide: development, characterization and investigation on pharmacokinetics and pharmacological profile. Journal of Drug Delivery Science and Technology 2025, 112, 107290.
https://doi.org/10.1016/j.jddst.2025.107290
93. A.S. Kulkarni, S.R. Ramana, V.K. Nuthakki, S. Bhatt, A. Jamwal, L.D. Nandawadekar, A. Jotshi, A. Kumar, U. Nandi*, S.B. Bharate*, D.S. Reddy*. Silicon incorporated tacrine: design, synthesis, and evaluation of biological and pharmacokinetic parameters. RSC Medicinal Chemistry 2025, 16(6), 2603- 2614.
https://doi.org/10.1039/D5MD00019J
92. D. Kour, P. Khajuria, K. Sharma, A. Sharma, A. Sharma, S.M. Ali, P. Wazir, P. Ramajayan, S.D. Sawant, U. Nandi, Z. Ahmed, A. Kumar. Isobavachalcone ameliorates alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice. Frontiers in Pharmacology 2025, 16, 1525364.
https://doi.org/10.3389/fphar.2025.1525364
91. P. Anand, J. Chhimwal, S. Dhiman, Yamini, V. Patial, P. Das, Z. Ahmed, U. Nandi, M. Tavassoli, Y.Padwad. Evaluation of pyrrolone‐fused benzosuberene MK2 inhibitors as promising therapeutic agents for HNSCC: In vitro efficacy, in‐vivo safety, and pharmacokinetic profiling. Drug Development Research 2025, 86(2), e70062.
https://doi.org/10.1002/ddr.70062
90. S. Saini, G.L. Reddy, A. Gangwar, H. Kour, G.G. Nadre, R. Pandian, S. Pal, U. Nandi, R. Sharma, S.D. Sawant. Discovery and biological evaluation of nitrofuranyl-pyrazolopyrimidine hybrid conjugates as potent antimicrobial agents targeting Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. RSC Medicinal Chemistry 2025, 16, 1304-1328.
https://doi.org/10.1039/D4MD00826J
2024
89. P.S. Cham, A. Singh, A. Jamwal, R. Singh, R. Anand, D. Manhas, S. Sharma, V.P. Singh, U. Nandi*, S. K. Singh*, P. P. Singh*. Discovery of ring-annulated analogues of cannabidiol as potential anticancer agents: synthesis and biological evaluation. ACS Medicinal Chemistry Letters 2024, 15(11), 1832-1842.
https://doi.org/10.1021/acsmedchemlett.4c00233
88. S. Choudhary, V. Kumar, K. Sharma, A. Gour, A. Sahrawat, A. Jotshi, D. Manhas, U. Nandi, S. B. Bharate, Z. Ahmed, A. Kumar. Crocetin delays brain and body aging by increasing cellular energy levels in aged C57BL/6J mice. ACS Pharmacology & Translational Science 2024, 7(10), 3017-3033.
https://doi.org/10.22541/au.169639653.39291350/v1
87. D. Manhas, S. Dhiman, H. Kour, D. Kour, K. Sharma, P. Wazir, B. Vij, A. Kumar, S.D. Sawant, Z. Ahmed, U. Nandi*. ADME/PK insights of crocetin: a molecule having an unusual chemical structure with druglike features. ACS Omega 2024, 9(19), 21494-21509.
https://doi.org/10.1021/acsomega.4c02116
86. M. Bhardwaj, D. Kour, G. Rai, S. Bhattacharya, D. Manhas, B. Vij, A. Kumar, D. Mukherjee, Z. Ahmed, S.G. Gandhi*, U. Nandi*. EIDD-1931 treatment tweaks CYP3A4 and CYP2C8 in arthritic rats to expedite drug interaction: implication in oral therapy of molnupiravir. ACS Omega 2024, 9(12), 13982-13993.
https://doi.org/10.1021/acsomega.3c09287
85. M.O. Ayaz, A.Q. Bhat, Z. Akhter, N. Badsera, M.M. Hossain, F. Showket, S. Parveen, M.S. Dar, H. Tiwari, N. Kumari, M. Bhardwaj, R. Hussain, A. Sharma, M. Kumar, U. Singh, A. Nargorta, A.S. Kshatri, U. Nandi, S.P. Monga, P. Ramajayan, P.P. Singh, M.J. Dar. Identification of a novel GSK3β inhibitor involved in abrogating KRas dependent pancreatic tumors in Wnt/beta-catenin and NF-kB dependent manner. Life Sciences 2024, 351, 122840.
https://doi.org/10.1016/j.lfs.2024.122840
84. M.M. Hossain, A. Khalid, Z. Akhter, S. Parveen, M.O. Ayaz, A.Q. Bhat, N. Badesra, F. Showket, M.S. Dar, F. Ahmed, S. Dhiman, M. Kumar, U. Singh, R. Hussain, P. Keshari, G. Mustafa, A. Nargorta, N. Taneja, S. Gupta, R.A. Mir, A.S. Kshatri, U. Nandi, N. Khan, P. Ramajayan, G. Yadav, Z. Ahmed, P.P. Singh, M.J. Dar. Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter. Journal of Translational Medicine 2024, 22(1), 370.
https://doi.org/10.1186/s12967-024-05144-4
83. S.A. Haq, G. Paudwal, N. Banjare, N.I. Andrabi, P. Wazir, U. Nandi, Z. Ahmed, P. N. Gupta. Sustained release polymer and surfactant based solid dispersion of andrographolide exhibited improved solubility, dissolution, pharmacokinetics, and pharmacological activity. International Journal of Pharmaceutics 2024, 651, 123786.
https://doi.org/10.1016/j.ijpharm.2024.123786
82. R. Bhat, A. Dogra, S. Chib, M. Kumar, I.A. Khan*, U. Nandi*, S. Saran*. Development of mupirocin-impregnated bacterial cellulosic transdermal patches for the management of skin infection. ACS Omega 2024, 9(5), 5496-5508.
https://doi.org/10.1021/acsomega.3c07174
81. A. Sharma, S. Kaur, A. Wani, D. Kour, M. Ali, S.M. Ali, L. Singh, A. Gour, U. Nandi, M. Datt, P.R. Sharma, C.C. Weihl, G. Singh, A. Kumar. Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes. Autophagy Reports 2024, 3(1), 2296209.
https://doi.org/10.1080/27694127.2023.2296209
80. P.S. Cham, P. Kotwal, K. Sharma, S. Dhiman, L. Singh, V.P. Singh, A. Kumar, U. Nandi*, P.P. Singh*. Cannabidiol-based prodrugs: synthesis and bio evaluation. ACS Medicinal Chemistry Letters 2024, 15(2), 221-229.
https://doi.org/10.1021/acsmedchemlett.3c00461
79. M. Deb, H. Singh, D. Manhas, U. Nandi, S.K. Guru, P. Das. Development of di-arylated 1, 2, 4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation. RSC Medicinal Chemistry 2024, 15(9), 3097-3113.
https://doi.org/10.1039/D4MD00285G
2023
78. R.P. Shah, P. Wazir, U. Nandi, S.S. Bharate. Self‐emulsifying drug delivery of khellin for improving its oral bioavailability. Chemistry Select 2023, 8(46), e202302620.
https://doi.org/10.1002/slct.202302620
77. P.S. Cham, Deepika, R. Bhat, D. Raina, D. Manhas, P. Kotwal, D.P. Mindala, N. Pandey, A. Ghosh, S. Saran, U. Nandi, I.A. Khan, P.P. Singh. Exploring the antibacterial potential of semisynthetic phytocannabinoid: tetrahydrocannabidiol (THCBD) as a potential antibacterial agent against sensitive and resistant strains of Staphylococcus aureus. ACS Infectious Diseases 2023, 10(1), 64-78.
https://doi.org/10.1021/acsinfecdis.3c00154
76. A. Gour, A. Dogra, M.K. Verma, M. Bhardwaj, D. Kour, A. Jamwal, B. Gorain, M. Kumar, B. Vij, A. Kumar, U. Nandi*. Ayurveda-based phytochemical composition attenuates lung inflammation and precipitates pharmacokinetic interaction with favipiravir: an in vivo investigation using disease-state of acute lung injury. Natural Product Research 2023, 37(22), 3758-3765.
https://doi.org/10.1080/14786419.2022.2150620
75. S.S. Shete, F. Iqbal, M. Bhardwaj, U. Nandi*, A. Kumar*, D.S. Reddy*. Sila-CBD derivatives as inhibitors of heme-induced NLRP3 inflammasome: application in hemolytic diseases. ACS Medicinal Chemistry Letters 2023, 14(12), 1716-1723.
https://doi.org/10.1021/acsmedchemlett.3c00352
74. T. Amin, R.P. Sharma, K.B. Mir, N. Slathia, S. Chhabra, D. Tsering, P. Kotwal, M. Bhagat, U. Nandi, R. Parkesh, K.K. Kapoor, A. Goswami. Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial membrane potential. European Journal of Pharmacology 2023, 957, 175945.
https://doi.org/10.1016/j.ejphar.2023.175945
73. D. Bhurta, M.M. Hossain, M. Bhardwaj, F. Showket, U. Nandi, M.J. Dar, S.B. Bharate. Orally bioavailable styryl derivative of rohitukine-N-oxide inhibits CDK9/T1 and the growth of pancreatic cancer cells. European Journal of Medicinal Chemistry 2023, 258, 115533.
https://doi.org/10.1016/j.ejmech.2023.115533
72. M. Sharma, A. Sharma, S. Thakur, V.K. Nuthakki, A. Jamwal, U. Nandi, H.R. Jadhav, S.B. Bharate. Discovery of blood-brain barrier permeable and orally bioavailable caffeine-based amide derivatives as acetylcholinesterase inhibitors. Bioorganic Chemistry 2023, 139, 106719.
https://doi.org/10.1016/j.bioorg.2023.106719
71. A. Jamwal, J. Chand, A. Dash, S. Bhatt, S. Dhiman, P. Wazir, B. Singh, A. Goswami*, U. Nandi*. Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer. Chemico-Biological Interactions 2023, 382, 110605.
https://doi.org/10.1016/j.cbi.2023.110605
70. A. Kumar, A. Gour, S. Dhiman, N. Hudait, P. Kumar, D. Vashishth, S. Kaur, S.T. Abdullah, U. Nandi, D. Mukherjee. Stereoselective and regioselective Heck arylation at C-17 exocyclic double bond of andrographolide to generate labdane-based lead molecule against acute lung injury. Journal of Molecular Structure 2023, 1286, 135568.
https://doi.org/10.1016/j.molstruc.2023.135568
69. A.S. Kulkarni, A. Dash, R.D. Shingare, J. Chand, D. Manhas, A. Singh, U. Nandi, A. Goswami, D.S. Reddy. Identification of new modulator of DNA repairing pathways based on natural product (±)-peharmaline A. Bioorganic & Medicinal Chemistry 2023, 91, 117365.
https://doi.org/10.1016/j.bmc.2023.117365
68. M. Bhardwaj, A. Gour, A. Ahmed, S. Dhiman, D. Manhas, P. Khajuria, P. Wazir, D. Mukherjee, Utpal Nandi*. Impact of disease states on the oral pharmacokinetics of EIDD-1931 (an active form of molnupiravir) in rats for implication in the dose adjustment. Molecular Pharmaceutics 2023, 20(9), 4597-4610.
https://doi.org/10.1021/acs.molpharmaceut.3c00314
67. D. Manhas, S. Bhatt, G. Rai, V. Kumar, S. Bharti, S. Dhiman, S.K. Jain, D.K. Sharma, P.K. Ojha, S.G. Gandhi, A. Goswami, U. Nandi*. Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy. Chemico-Biological Interactions 2023, 380, 110524.
https://doi.org/10.1016/j.cbi.2023.110524
66. D.S. Gupta, P. Kotwal, U. Nandi, S.S. Bharate. Amorphous solid dispersion of niclosamide with water‐soluble β‐cyclodextrins for dissolution and bioavailability enhancement. ChemistrySelect 2023, 8(19), e202300492.
https://doi.org/10.1002/slct.202300492
65. A. Gour, D. Kour, R. Pandian, M. Bhardwaj, S.D. Sawant, A. Kumar, U. Nandi*. Ellagic acid exerts dual action to curb the pathophysiological manifestations of sickle cell disease and attenuate the hydroxyurea-induced myelosuppression in berkeley mice. ACS Pharmacology & Translational Science 2023, 6(6), 868-877.
https://doi.org/10.1021/acsptsci.3c00026
64. P. Kotwal, P. Khajuria, S. Dhiman, D. Kour, S.K. Dhiman, A. Kumar, U. Nandi*. Molecular mechanism for the involvement of CYP2E1/NF-κB axis in bedaquiline-induced hepatotoxicity. Life Sciences 2023, 315, 121375.
https://doi.org/10.1016/j.lfs.2023.121375
63. A.D. Hudwekar, P. Kotwal, M.I. Dar, S. Balgotra, A. Dogra, J. Kour, S.S. Chobe, U. Nandi, S.H. Syed, S.D. Sawant. Pyrazolopyrimidinone based selective inhibitors of PDE5 for the treatment of erectile dysfunction. Chemistry & Biodiversity 2023, 20(4), e202200707.
https://doi.org/10.1002/cbdv.202200707
62. D. Singh, I. Qasam, G. Paudwal, P. Kotwal, C. Behera, A. Kumar, A.P. Gupta, U. Nandi, G. Yadav, P.N. Gupta, R. Shankar. Redox-responsive hyaluronic acid–tacrolimus conjugate: synthesis, characterization, and in vitro immunosuppressive activity. ACS Applied Bio Materials 2023, 6(2), 733-744.
https://doi.org/10.1021/acsabm.2c00946
61. V.K. Nuthakki, S. Choudhary, C.N. Reddy, S. Bhatt, A. Jamwal, A. Jotshi, R. Raghuvanshi, A. Sharma, S. Thakur, H.R. Jadhav, S.S. Bharate, U. Nandi, A. Kumar, S.B. Bharate. Design, synthesis, and pharmacological evaluation of embelin–aryl/alkyl amine hybrids as orally bioavailable blood–brain barrier permeable multitargeted agents with therapeutic potential in Alzheimer’s disease: discovery of SB-1448. ACS Chemical Neuroscience 2023, 14(6), 1193-1219.
https://doi.org/10.1021/acschemneuro.3c00030
60. A. Dogra*, D. Kour, A. Gour, M. Bhardwaj, S. Bag, SK. Dhiman, A. Kumar, G. Singh, U. Nandi*. Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP. Drug and Chemical Toxicology 2023, 46(3), 597-608.
https://doi.org/10.1080/01480545.2022.2069804
59. R. Raghuvanshi, A. Jamwal, U. Nandi, S.B. Bharate. Multitargeted C9‐substituted ester and ether derivatives of berberrubine for Alzheimer's disease: design, synthesis, biological evaluation, metabolic stability, and pharmacokinetics. Drug Development Research 2023, 84(1), 121-140.
https://doi.org/10.1002/ddr.22017
58. S. Malik, M.J. Mintoo, C.N. Reddy, R. Kumar, P. Kotwal, S.B. Bharate, U. Nandi, D.M. Mondhe, S.K. Shukla. In vitro and in vivo anticancer potential and molecular targets of the new colchicine analog IIIM-067. Journal of Integrative Medicine 2023, 21(1), 62-76.
https://doi.org/10.1016/j.joim.2022.09.006
2022
57. J.S. Bhanushali, S. Dhiman, U. Nandi, S.S. Bharate. Molecular interactions of niclosamide with hydroxyethyl cellulose in binary and ternary amorphous solid dispersions for synergistic enhancement of water solubility and oral pharmacokinetics in rats. International Journal of Pharmaceutics 2022, 626, 122144.
https://doi.org/10.1016/j.ijpharm.2022.122144
56. P. Roy, N. Kumari, N. Pandey, A. Gour, A. Raj, B. Srividya, U. Nandi, A. Ghosh. Development of ezetimibe eutectic with improved biopharmaceutical and mechanical properties to design an optimized oral solid dosage formulation. Pharmaceutical Development and Technology 2022, 27(10), 989-998.
https://doi.org/10.1080/10837450.2022.2143525
55. M. Sharma, A. Sharma, V.K. Nuthakki, S. Bhatt, U. Nandi, S.B. Bharate. Design, synthesis, and structure-activity relationship of caffeine-based triazoles as dual AChE and BACE-1 inhibitors. Drug Development Research 2022, 83(8), 1803-1821.
https://doi.org/10.1002/ddr.21998
54. A. Dogra, D. Kour, M. Bhardwaj, S. Dhiman, A. Kumar, B. Vij, A. Kumar, U. Nandi*. Glabridin Plays dual action to augment the efficacy and attenuate the hepatotoxicity of methotrexate in arthritic rats. ACS Omega 2022, 7(38), 34341-34351.
https://doi.org/10.1021/acsomega.2c03948
53. R.S. Manhas, S.M. Ahmad, K.B. Mir, A. Ahmed, S. Sharma, D. Manhas, H. Tiwari, A. Kumar, A. Nargotra, U. Nandi, D. Mukherjee, A. Goswami, A. Chaubey. Isolation and anticancer activity evaluation of rare bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region. Chemico-Biological Interactions 2022, 365, 110093.
https://doi.org/10.1016/j.cbi.2022.110093
52. D. Manhas, K.B. Mir, N. Tripathi, S. Bharti, S. Dhiman, P. Wazir, D.K. Sharma, A. Goswami*, U. Nandi*. Rottlerin promotes anti-metastatic events by ameliorating pharmacological parameters of paclitaxel: an in-vivo investigation in the orthotopic mouse model of breast cancer. Chemico-Biological Interactions 2022, 366, 110109.
https://doi.org/10.1016/j.cbi.2022.110109
51. A. Gour, D. Kour, A. Dogra, D. Manhas, P. Wazir, S.K. Digra, A. Kumar, U. Nandi*. Epicatechin exerts dual action to shield sickling and hydroxyurea-induced myelosuppression: implication in sickle cell anemia management. Toxicology and Applied Pharmacology 2022, 449, 116113.
https://doi.org/10.1016/j.taap.2022.116113
50. S. Bhatt, S. Dhiman, V. Kumar, A. Gour, D. Manhas, K. Sharma, P.K. Ojha, U. Nandi*. Assessment of the CYP1A2 inhibition-mediated drug interaction potential for pinocembrin using in silico, in vitro, and in vivo approaches. ACS Omega 2022, 7 (23), 20321-20331.
https://doi.org/10.1021/acsomega.2c02315
49. S.K. Dar, S. Kumar, S. Maiti, S. Dhawan, S. Joglekar, U. Arora, R. Kalra, S. Madan, A.A. Lal, V. Singamaneni, P. Gupta, U. Nandi, D. Singh, A.H. Khuroo. Clinical safety and pharmacokinetic evaluation of aqueous extract of Cocculus hirsutus, an anti-viral phytopharmaceutical drug as a potential for the treatment of dengue and COVID-19. Heliyon 2022, 8 (5), e09416.
https://doi.org/10.1016/j.heliyon.2022.e09416
48. A. Qayum, J. Singh, A. Kumar, S.M. Shah, S. Srivastava, M. Kushwaha, A. Magotra, U. Nandi, R. Malik, B.A. Shah, S.K. Singh. 2-Pyridin-4-yl-methylene-beta-boswellic acid-a potential candidate for targeting O6-methylguanine-DNA methyltransferase epi-transcriptional reprogramming in KRAS G13D-microsatellite stable, G12V-microsatellite instable mutant colon cancer. ACS Pharmacology & Translational Science 2022, 5 (5), 306-320.
https://doi.org/10.1021/acsptsci.1c00228
47. S. Bhatt, D. Manhas, V. Kumar, A. Gour, K. Sharma, A. Dogra, P.K. Ojha, U. Nandi*. Effect of myricetin on CYP2C8 inhibition to assess likelihood of drug interaction using in silico, in vitro and in vivo approaches. ACS Omega 2022, 7 (15), 13260-13269.
https://doi.org/10.1021/acsomega.2c00726
46. A. Gour, P. Kotwal, A. Dogra, D. Kour, S. Dhiman, A. Kumar, S.K. Digra, A. Kumar, G. Singh, U. Nandi*. Investigating the potential use of andrographolide as co-adjuvant in sickle cell anemia therapy. ACS Omega 2022, 7(15), 12765-12771.
https://doi.org/10.1021/acsomega.1c07339
45. A. Qayum, A. Magotra, S.M. Shah, U. Nandi, P.R. Sharma, B.A. Shah, S.K. Singh. Synergistic combination of PMBA and 5-fluorouracil (5-FU) in targeting mutant KRAS in 2D and 3D colorectal cancer cells. Heliyon 2022, 8(4), e09103.
https://doi.org/10.1016/j.heliyon.2022.e09103
44. S. Bhatt, A. Sharma, A. Dogra, P. Sharma, A. Kumar, P. Kotwal, S. Bag, P. Misra, G. Singh, A. Kumar, P.L. Sangwan*, U. Nandi*. Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress. Drug and Chemical Toxicology 2022, 45(5), 2352-2360.
https://doi.org/10.1080/01480545.2021.1945004
2021
43. A. Gour, A. Dogra, D. Kour, G. Singh, A. Kumar, U. Nandi*. Effect of concomitant hydroxyurea therapy with rutin and gallic acid: integration of pharmacokinetic and pharmacodynamic approaches. ACS Omega 2021, 6(22), 14542-14550.
https://doi.org/10.1021/acsomega.1c01518
42. D. Manhas, A. Gour, N. Bhardwaj, D.K. Sharma, K. Sharma, B. Vij, S.K. Jain, G. Singh, U. Nandi*. Pharmacokinetic assessment of rottlerin from Mallotus philippensis using a highly sensitive liquid chromatography–tandem mass spectrometry-based bioanalytical method. ACS Omega 2021, 6(48), 32637-32646.
https://doi.org/10.1021/acsomega.1c04266
41. A. Dogra, D. Gupta, S. Bag, I. Ahmed, S. Bhatt, E. Nehra, S. Dhiman, A. Kumar, G. Singh, S.T. Abdullah, P.L. Sangwan*, U. Nandi*. Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis. Life Sciences 2021, 278, 119583.
https://doi.org/10.1016/j.lfs.2021.119583
40. A. Gour, A. Dogra, S. Sharma, P. Wazir, U. Nandi*. Effect of disease state on the pharmacokinetics of bedaquiline in renal impaired and diabetic rats. ACS Omega 2021, 6(10), 6934-6941.
https://doi.org/10.1021/acsomega.0c06165
39. S. Bhatt, V. Kumar, A. Dogra, P.K. Ojha, P. Wazir, P.L. Sangwan, G. Singh, U. Nandi*. Amalgamation of in-silico, in-vitro and in-vivo approach to establish glabridin as a potential CYP2E1 inhibitor. Xenobiotica 2021, 51(6), 625-635.
https://doi.org/10.1080/00498254.2021.1883769
38. A. Wani, S.B. Al Rihani, A. Sharma, B. Weadick, R. Govindarajan, S.U. Khan, P.R. Sharma, A. Dogra, U. Nandi, C.N. Reddy, S.S. Bharate, G. Singh, S.B. Bharate, R.A. Vishwakarma, A. Kaddoumi, A. Kumar. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy 2021, 17(11), 3813-3832.
https://doi.org/10.1080/15548627.2021.1872187
37. M. Singh, N. Schiavone, L. Papucci, P. Maan, J. Kaur, G. Singh, U. Nandi, D. Nosi, A. Tani, G.K. Khuller, M. Priya, R. Singh, I.P. Kaur. Streptomycin sulphate loaded solid lipid nanoparticles show enhanced uptake in macrophage, lower MIC in mycobacterium and improved oral bioavailability. European Journal of Pharmaceutics and Biopharmaceutics 2021, 160, 100-124.
https://doi.org/10.1016/j.ejpb.2021.01.009
2020
36. A. Dogra, P. Kotwal, A. Gour, S. Bhatt, G. Singh, D. Mukherjee, U. Nandi*. Description of drug like properties of safranal and its chemistry behind low oral exposure. ACS Omega 2020, 5(17), 9885-9891.
https://doi.org/10.1021/acsomega.0c00160
35. A. Dogra, A. Gour, S. Bhatt, P. Sharma, A. Sharma, P. Kotwal, P. Wazir, P. Mishra, G. Singh, U Nandi*. Effect of rutin on pharmacokinetic modulation of diclofenac in rats. Xenobiotica 2020, 50(11), 1332-1340.
https://doi.org/10.1080/00498254.2020.1773008
34. A. Gour, A. Dogra, P. Wazir, G. Singh, U. Nandi*. A highly sensitive UPLC-MS/MS method for hydroxyurea to assess pharmacokinetic intervention by phytotherapeutics in rats. Journal of Chromatography B 2020, 1154, 122283.
https://doi.org/10.1016/j.jchromb.2020.122283
33. P. Kotwal, A. Dogra, A. Sharma, S. Bhatt, A. Gour, S. Sharma, P. Wazir, P.P. Singh, A. Kumar, U. Nandi*. Effect of natural phenolics on pharmacokinetic modulation of bedaquiline in rat to assess the likelihood of potential food-drug interaction. Journal of Agricultural and Food Chemistry 2020, 68(5), 1257-1265.
https://doi.org/10.1021/acs.jafc.9b06529
2019
32. G.L. Reddy, M.I. Dar, A.D. Hudwekar, P. Mahajan, A. Nargotra, A.M. Baba, U. Nandi, P. Wazir, G. Singh, R.A. Vishwakarma, S.H. Syed, S.D. Sawant. Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction. Bioorganic Chemistry 2019, 89, 103022.
https://doi.org/10.1016/j.bioorg.2019.103022
31. S. Chib, A. Dogra, U. Nandi, S. Saran. Consistent production of kojic acid from Aspergillus sojae SSC-3 isolated from rice husk. Molecular Biology Reports 2019, 46, 5995-6002.
https://doi.org/10.1007/s11033-019-05035-8
30. A. Sharma, A. Gour, S. Bhatt, S.K. Rath, T.A. Malik, A. Dogra, P.L. Sangwan, S. Koul, S.T. Abdullah, G. Singh, U. Nandi*. Effect of IS01957, a para- coumaric acid derivative on pharmacokinetic modulation of diclofenac through oral route for augmented efficacy. Drug Development Research 2019, 80(7), 948-957.
https://doi.org/10.1002/ddr.21574
29. I.A. Khan, A. Singh, D.P. Mindala, S. Meena, B. Vij, A.K. Yadav, S. Roy, U. Nandi, A.K. Katare, S. Jaglan, D. Singh, A.P. Gupta, P. Gupta, S. Singh, M.K. Tikko, G. Singh, R.A. Vishwakarma. Preclinical development of gastro-protective botanical candidate from Woodfordia fruticosa (Linn.) Kurz: chemical standardization, efficacy, pharmacokinetics and safety pharmacology. Journal of Ethnopharmacology 2019, 241, 112023.
https://doi.org/10.1016/j.jep.2019.112023
28. A. Magotra, A. Gour, D.K. Sharma, A.K. Dash, G. Singh, D. Mukherjee*, U. Nandi*. Pharmacokinetic evaluation of medicinally important synthetic N, N′ diindolylmethane glucoside: improved synthesis and metabolic stability. Bioorganic & Medicinal Chemistry Letters 2019, 29(8), 1007-1011.
https://doi.org/10.1016/j.bmcl.2019.02.010
27. P. Kotwal, A. Magotra, A. Dogra, S. Sharma, A. Gour, S. Bhatt, P. Wazir, P.P. Singh, G. Singh, U. Nandi*. Assessment of preclinical drug interactions of bedaquiline by a highly sensitive LC-ESI-MS/MS based bioanalytical method. Journal of Chromatography B 2019, 1112, 48-55.
https://doi.org/10.1016/j.jchromb.2019.02.022
2018
26. A. Dogra, S. Bhatt, A. Magotra, A. Sharma, P. Kotwal, A. Gour, P. Wazir, G. Singh, U. Nandi*. Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: a possible risk for long‐term use. Phytotherapy Research 2018, 32(10), 1967-1974.
https://doi.org/10.1002/ptr.6123
25. A. Sharma, A. Magotra, S. Bhatt, A. Dogra, P. Wazir, N.K. Satti, G. Singh, S.S. Bhusari, U. Nandi*. Potential herb-drug interaction of a flavone glycoside from Cuminum cyminum: possible pathway for bioenhancement of rifampicin. Indian Journal of Traditional Knowledge 2018, 17(4), 776-782.
https://nopr.niscair.res.in/handle/123456789/45054
24. A. Sharma, A. Magotra, S.K. Rath, P. Wazir, U. Nandi, S. Koul, P.L. Sangwan, A.P. Gupta, G. Singh. In-vitro and in-vivo pharmacokinetics of IS01957, p-coumaric acid derivative using a validated LC–ESI–MS/MS method in mice plasma. Journal of Pharmaceutical Investigation 2018, 48(5), 565-574.
https://doi.org/10.1007/s40005-017-0350-8
23. F. Kouser, V.K. Sharma, M. Rizvi, S. Sultan, N. Chalotra, V.K. Gupta, U. Nandi, B.A. Shah. Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols. Tetrahedron Letters 2018, 59(22), 2161-2166.
https://doi.org/10.1016/j.tetlet.2018.04.046
22. A. Singh, T. Thatikonda, A. Kumar, P. Wazir, V. Vijayabhaskar, U. Nandi, P.P. Singh, S. Singh, A.P. Gupta, M.K. Tikoo, G. Singh, R.A. Vishwakarma. Determination of ZSTK474, a novel Pan PI3K inhibitor in mouse plasma by LC-MS/MS and its application to pharmacokinetics. Journal of Pharmaceutical and Biomedical Analysis 2018, 149, 387-393.
https://doi.org/10.1016/j.jpba.2017.11.031
21. F. Ali, U. Nandi, M. Trivedi, A. Prakash, M. Dahiya, P.L. Sahu, R. Kumar, G.N. Singh. Quantitative characterization and pharmaceutical compatibility between teneligliptin and widely used excipients by using thermal and liquid chromatography tandem mass spectrometry techniques. Journal of Thermal Analysis and Calorimetry 2018, 132(1), 385-396.
https://doi.org/10.1007/s10973-018-6962-z
20. G.A. Rather, A. Sharma, S.A. Pandith, V. Kaul, U. Nandi, P. Misra, S.K. Lattoo. De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) Mabb. Plant Molecular Biology 2018, 96, 197-215.
https://doi.org/10.1007/s11103-017-0690-9
19. A. Magotra, A. Sharma, S. Singh, P. K. Ojha, S. Kumar, N. Bokolia, P. Wazir, S. Sharma, I.A. Khan, P.P. Singh, R.A. Vishwakarma, G. Singh*, U. Nandi*. Physicochemical, pharmacokinetic, efficacy and toxicity profiling of a potential nitrofuranyl methyl piperazine derivative IIIM-MCD-211 for oral tuberculosis therapy via in-silico - in-vitro - in-vivo approach. Pulmonary Pharmacology & Therapeutics 2018, 48, 151-160.
https://doi.org/10.1016/j.pupt.2017.11.006
18. U. Nandi, M. Dahiya, A. Prakash, R. Kumar, G.N. Singh. Compatibility study of alogliptin benzoate with widely used pharmaceutical excipients for solid dosage form. Indian Drugs 2018, 55(2), 20-26.
https://doi.org/10.53879/id.55.02.10907
2017
17. U. Singh, G. Chashoo, S.U. Khan, P. Mahajan, A. Nargotra, G. Mahajan, A. Singh, A. Sharma, M.J. Mintoo, S.K. Guru, H. Aruri, T. Thatikonda, P. Sahu, P. Chibber, V. Kumar, S.A. Mir, S.S. Bharate, S. Madishetti, U. Nandi, G. Singh, D.M. Mondhe, S. Bhushan, F. Malik, S. Mignani, R.A. Vishwakarma, P.P. Singh. Design of novel 3-pyrimidinylazaindole based CDK2/9 inhibitors with potent in-vitro and in-vivo antitumor efficacy in a triple-negative breast cancer model. Journal of Medicinal Chemistry 2017, 60(23), 9470-9489.
https://doi.org/10.1021/acs.jmedchem.7b00663
16. A. Sharma, A. Magotra, A. Dogra, S.K. Rath, S. Rayees, P. Wazir, S. Sharma, P.L. Sangwan, S. Singh, G. Singh*, U. Nandi*. Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception. Regulatory Toxicology and Pharmacology 2017, 91, 216-225.
https://doi.org/10.1016/j.yrtph.2017.10.033
15. A. Magotra , A. Sharma , A.P. Gupta, P. Wazir, S. Sharma, P.P. Singh, M.K. Tikoo, R.A. Vishwakarma, G. Singh*, U. Nandi*. Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperizine derivative with potential activity against tuberculosis: application to drug development. Journal of Chromatography B 2017, 1060, 200-206.
https://doi.org/10.1016/j.jchromb.2017.06.015
14. A. Sharma, A. Magotra, U. Nandi, G. Singh. Enhancement of paclitaxel oral bioavailability in swiss mice by four consecutive days of pretreatment with curcumin. Indian Journal of Pharmaceutical Education & Research 2017, 51(4s), s566- s570.
https://archives.ijper.org/article/730
13. U. Nandi, S. Trikha, A. Wadhwa, A. Prakash, R. Kumar, P.L. Sahu, G.N. Singh. Synthesis and characterization of RS-4-amino-3-(4-chlorophenyl)-butyric acid: baclofen impurity-A as per Indian pharmacopoeia. Indian Journal of Chemistry 2017, 56, 165-170.
https://nopr.niscpr.res.in/handle/123456789/40523
2008-2016
12. U. Nandi, S. Dan, T. K. Pal. Development and validation of a liquid chromatography–mass spectrometry method for simultaneous determination of metoprolol and telmisartan in rat plasma and its application to pharmacokinetic study. Journal of Pharmaceutical Investigation 2015, 45(3), 329-340.
https://doi.org/10.1007/s40005-015-0180-5
11. B. Gorain, H. Choudhury, U. Nandi, A. Das, S. Dan, T.K. Pal. Development and validation of an HPLC-UV method for simultaneous detection and quantification of paracetamol and etodolac in human plasma and its application to pharmacokinetic study. The Journal of AOAC International 2013, 96(3), 573-579.
https://doi.org/10.5740/jaoacint.11-457
10. U. Nandi, S. Karmakar, A.K. Das, B. Ghosh, A. Padman, N. Chatterjee, T.K. Pal. Pharmacokinetics, pharmacodynamics and toxicity of a combination of metoprolol succinate and telmisartan in Wistar albino rats: safety profiling. Regulatory Toxicology and Pharmacology 2013, 65(1), 68-78.
https://doi.org/10.1016/j.yrtph.2012.11.001
09. U. Nandi, A. Das, B. Roy, H. Choudhury, B. Gorain, T.K. Pal. Development and validation of an HPLC-UV method for simultaneous determination of zidovudine, lamivudine and nevirapine in human plasma and its application to pharmacokinetic study in human volunteers. Drug Testing and Analysis 2013, 5(6), 485-491.
https://doi.org/10.1002/dta.419
08. U. Nandi, B. Roy, A.K. Das, T.K. Pal. Correlation among the toxicity profiling (28-days repeated oral dose toxicity), toxicokinetics and tissue distribution data of ulifloxacin, the active metabolite of prulifloxacin in Wistar albino rats. Environmental Toxicology and Pharmacology 2012, 34(2), 588-607.
https://doi.org/10.1016/j.etap.2012.07.001
07. P. Sengupta, U. Nandi, T.K. Pal. Development of safety profile evaluating pharmacokinetics, pharmacodynamics and toxicity of a combination of pioglitazone and olmesartan medoxomil in Wistar albino rats. Regulatory Toxicology and Pharmacology 2012, 62(1), 7-15.
https://doi.org/10.1016/j.yrtph.2011.12.008
06. B. Roy, U. Nandi, A. Das, T.K. Pal. Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats. Environmental Toxicology and Pharmacology 2011, 32(1), 82-101.
https://doi.org/10.1016/j.etap.2011.03.015
05. U. Nandi, U. Bhaumik, U.S. Chakrabarty, A. Das, T.K. Pal. Bioequivalence study of two tablet formulations containing rimonabant 20 mg in healthy Indian subjects. Arzneimittelforschung (Drug Research) 2011, 61(2), 80-84.
https://doi.org/10.1055/s-0031-1296171
04. A. Das, J. Mukherjee, G. Dey, A.K. Sarkar, B.K. Sahoo, U.S. Chakrabarty, U. Nandi, T.K. Pal. Bioequivalence study of levofloxacin tablets in healthy Indian volunteers using HPLC. Arzneimittelforschung (Drug Research) 2011, 61(1), 61-65.
https://doi.org/10.1055/s-0031-1296168
03. U. Bhaumik, A. Ghosh, B. Chatterjee, P. Sengupta, S. Darbar, B. Roy, U. Nandi, T.K. Pal. Development and validation of a high performance liquid chromatographic method for bioanalytical application with rimonabant. Journal of Pharmaceutical and Biomedical Analysis 2009, 49(4), 1009-1013.
https://doi.org/10.1016/j.jpba.2009.01.032
02. U.S. Chakrabarty, A. Das, U. Bhaumik, B. Chatterjee, A. Ghosh, A. Bose, P. Sengupta, U. Nandi, T.K. Pal. Rapid and sensitive LC method for analysis of gemifloxacin in human plasma. Chromatographia 2009, 69(9), 853-858.
https://doi.org/10.1365/s10337-009-0981-7
01. U. Mandal, A. Das, S. Agarwal, U. Chakraborty, U. Nandi, T.K. Chattaraj, T.K. Pal. Bioequivalence study of two formulations containing 400 mg dexibuprofen in healthy Indian subjects. Arzneimittelforschung (Drug Research) 2008, 58(7), 342-347.
https://doi.org/10.1055/s-0031-1296517
-
Review Articles
04. N. Sakander, A. Ahmed, M. Bhardwaj, D. Kumari, U. Nandi, D. Mukherjee. A path from synthesis to emergency use authorization of molnupiravir as a COVID-19 therapy. Bioorganic Chemistry 2024, 147, 107379.
https://doi.org/10.1016/j.bioorg.2024.107379
03. A. Gour, D. Manhas, S. Bag, B. Gorain, U. Nandi*. Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV‐2. Phytotherapy Research 2021, 35(8), 4258-4283.
https://doi.org/10.1002/ptr.7092
02. A. Dogra, A. Sharma, U.K. Mandal, P. Kotwal, S. Bhatt, U. Nandi*. Liquid chromatography-based methods for analysis of disease-modifying antirheumatic drugs (DMARDs) in biological matrices. Critical Reviews in Analytical Chemistry 2019, 49(3), 224-242.
https://doi.org/10.1080/10408347.2018.1503943
01. M. Pal, U. Nandi, D. Mukherjee. Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents. European Journal of Medicinal Chemistry 2018, 150, 419-445.
-
Book Chapters
07. A. Gour, S. Bhatt, D. Manhas, A. Jamwal, U. Nandi*. 2024. Chapter entitled ‘Therapeutic potential of swertisin: a flavone-C-glycoside from natural plant sources’ in the book ‘Traditional medicines in drug discovery and development’. Chapter 8, p. 254-287, Cambridge Scholars Publishing.
https://www.cambridgescholars.com/resources/pdfs/978-1-0364-0345-4-sample.pdf
06. A. Gour, A. Dogra, U. Nandi*. 2023. Chapter entitled ‘Pharmacokinetic aspects of chromenes’ in the book entitled ‘The role of chromenes in drug discovery and development’. Chapter 7, p. 151-162, Bentham Science.
https://dx.doi.org/10.2174/97898151243301230101
05. S. Bhatt, A. Gour, G. Singh, U. Nandi*. 2020. Chapter entitled ‘Tuberculosis’ in the book entitled ‘Chronic Lung Diseases’. Chapter 5, p. 87-127, Springer Nature.
https://doi.org/10.1007/978-981-15-3734-9_5
04. A. Gour, A. Dogra, S. Bhatt, U. Nandi*. 2020. Chapter entitled ‘Effect of natural products on improvement of blood pathophysiology for management of sickle cell anemia’ in the book entitled ‘Botanical leads for drug discovery’. Chapter 3, p. 51-65, Springer Nature.
https://doi.org/10.1007/978-981-15-5917-4_3
03. B. Gorain, S. Dutta, U. Nandi, P. Sengupta, H. Choudhury, 2020. Chapter entitled ‘Pharmacology of Adrenaline, Noradrenaline, and their receptors’ in the book entitled ‘Frontiers in Pharmacology of Neurotransmitters’. Chapter 4, p. 107-142, Springer Nature.
https://doi.org/10.1007/978-981-15-3556-7_4
02. B. Gorain, S.K. Bhattamishra, H. Choudhury, U. Nandi, M. Pandey, P. Kesharwani. 2019. Chapter entitled ‘Overexpressed receptors and proteins in lung cancer’ in the book entitled ‘Nanotechnology-based targeted drug delivery systems for lung cancer’. Chapter 3, p. 39-75, Academic Press.
https://doi.org/10.1016/B978-0-12-815720-6.00003-4
01. A. Dogra, U.K. Mandal, U. Nandi*. 2018. Chapter entitled ‘Pharmacognosy, phytochemistry and pharmacology of Dysoxylum binectariferum’ in the book entitled ‘Recent Progress in Medicinal Plants (RPMP)’. Chapter 14, Volume 49-Inflammatory Disorders, p. 259-270, Studium Press.
-
Patents
06. S. Saran, M. Kumar, S. Chib, R. Bhat, U. Nandi, A. Dogra, I. A. Khan. A composition for anti-bacterial bio-cellulosic patches useful for transdermal drug delivery and a process for the preparation thereof. Filed (US20240360487A1).
05. P.S. Cham, A. Singh, A. Jamwal, R. Singh, Shabu, S. Thapa, P. Wazir, U. Nandi, S.K. Singh, P.P. Singh. Synthesis of (N-alkyldihydrol-2H-oxazinyl)-cannabidiol as anti-proliferative agents. Filed (IN202211074391).
04. F. Malik, Q.N. Ahmed, S.A. Mir, S. Khan, S.U. Khan, M.A. Paddar, L.K. Anand, M.S. Maqbool, A. Kumar, A. Padala, G. Chashoo, U. Nandi, G. Singh, B.A. Shah, B. Hamza, K. Fatim, N. Nazir, A. Dogra, A. Kumar, G. Yadav. Amino acid-containing imidazoles as potential stem cells modulator useful against paclitaxel-resistant triple negative breast cancer. Filed (IN202211066609).
03. P.S. Cham, P. Kotwal, K. Sharma, S. Kour, D.P. Mindala, A. Kumar, U. Nandi, P.P. Singh. Prodrugs of cannabidiol-type phytocannabinoids and their method of preparation. Filed (IN202211039597)
02. P.S. Cham, M. Singh, A. Verma, R. Anand, R. Singh, K. Sharma, P. Kotwal, A. Gour, P. Kumar, D.P. Mindala, S. Roy, C.P. Singh, S.R. Meena, A. Kumar, M.K. Verma, V.P. Rahul, U. Nandi, S. Gairola, A.K. Katare, D. Singh, P.L. Sangwan, D. Vyas, S.D. Sawant, G. Singh, R.A. Vishwakarma, D.S. Reddy, P.P. Singh. Process of phytocannabinoids enrichment, its formulation and use in the management of pain. Filed (IN202211028450).
01. S. Saran, M. Kumar, S. Chib, R. Bhat, U. Nandi, A. Dogra, I.A. Khan. Method for cost-effective production of bacterial cellulose membranes for transdermal drug delivery. Filed (IN202111044817).
